Kisara is a mysterious woman with an appearance unusual for an Egyptian: pale white skin, light white-blue hair, and bright blue eyes. This is probably due to the fact that she carries the spirit of the "Blue-Eyes White Dragon" within her. She is portrayed as being a gentle, pure and self-sacrificing girl. She appears weak at first, but later her inner strength is shown, from her Ka of the Blue-Eyes White Dragon.

After Akhenaden pledges his loyalty to Zorc Necrophades, he kidnaps Priest Seto - revealed to be his son - and tries to brainwash him into usurping Pharaoh Atem. Kisara is able to save him, although she dies taking a blow originally meant for Seto. (In the English version, Akhnaedan said he knew that Kisara would try to protect Seto, and it was an effort to try and weaken her.) Akhenaden is then able to seal the Blue-Eyes in a stone tablet, along with Kisara's spirit. However, she later uses her dragon to destroy Akhenaden and free Seto from his control. She then gives him her power, making him the new keeper of the Blue-Eyes White Dragon. After her death, Seto holds Kisara's body in front of the tablet - notably, this is the vision Kaiba sees during his battle with Ishizu in Battle City

.According to the manga, Kisara giving the spirit of the White dragon to him is the basis of Kaiba's modern-day obsession with the "Blue-Eyes White Dragon."